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Article

Astrocyte-Dependent Vulnerability to Excitotoxicity in Spermine Oxidase-Overexpressing Mouse.

Neuromolecular medicine - 1 Mar 2016

Cervetto Chiara, Vergani Laura, Passalacqua Mario, Ragazzoni Milena, Venturini Arianna, Cecconi Francesco, Berretta Nicola, Mercuri Nicola, D'Amelio Marcello, Maura Guido, Mariottini Paolo, Voci Adriana, Marcoli Manuela, Cervelli Manuela

Abstract excerpt

Transgenic mice overexpressing spermine oxidase (SMO) in the cerebral cortex (Dach-SMO mice) showed increased vulnerability to excitotoxic brain injury and kainate-induced epileptic seizures. To investigate the mechanisms by which SMO overexpression leads to increased susceptibility to kainate excitotoxicity and seizure, in the cerebral cortex of Dach-SMO and control mice we assessed markers for astrocyte...

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Identifiers

PMID: 26530396
DOI: 10.1007/s12017-015-8377-3

Genes

SMO

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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