Article
Risk prediction for clonal cytopenia: multicenter real-world evidence.
Blood - 7 Nov 2024
Xie Zhuoer, Komrokji Rami, Al Ali Najla, Regelson Alexandra, Geyer Susan, Patel Anand, Saygin Caner, Zeidan Amer M, Bewersdorf Jan Philipp, Mendez Lourdes, Kishtagari Ashwin, Zeidner Joshua F, Coombs Catherine C, Madanat Yazan F, Chung Stephen, Badar Talha, Foran James, Desai Pinkal, Tsai Charlton, Griffiths Elizabeth A, Al Malki Monzr M, Amanam Idoroenyi, Lai Catherine, Deeg H Joachim, Ades Lionel, Arana Yi Cecilia, Osman Afaf E G, Dinner Shira, Abaza Yasmin, Taylor Justin, Chandhok Namrata, Soong Deborah, Brunner Andrew M, Carraway Hetty E, Singh Abhay, Elena Chiara, Ferrari Jacqueline, Gallì Anna, Pozzi Sara, Padron Eric, Patnaik Mrinal M, Malcovati Luca, Savona Michael R, Al-Kali Aref
Abstract excerpt
ABSTRACT: Clonal cytopenia of undetermined significance (CCUS) represents a distinct disease entity characterized by myeloid-related somatic mutations with a variant allele fraction of ≥2% in individuals with unexplained cytopenia(s) but without a myeloid neoplasm (MN). Notably, CCUS carries a risk of progressing to MN, particularly in cases featuring high-risk mutations. Understanding CCUS requires dedicated...
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