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Genomic landscape of CCUS compared to MDS and its implications on risk prediction

10 May 2024

Abstract excerpt

The 5th edition of the WHO classification (WHO HAEM5) newly included myeloid precursor lesions introducing clonal cytopenia of undetermined significance (CCUS) as an entity [ 1 ]. CCUS is defined as clonal hematopoiesis (CH) in the presence of unexplained, persistent cytopenia requiring detection of either somatic mutations in certain genes or clonal chromosomal abnormalities. Discriminating CCUS from MDS...

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PMID: 38730270
DOI: 10.1038/s41375-024-02273-z

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