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The Clinical Challenge of Idiopathic Cytopenias of Undetermined Significance (ICUS) and Clonal Cytopenias of Undetermined Significance (CCUS).

Current hematologic malignancy reports - 1 Dec 2019

Steensma David P

Abstract excerpt

PURPOSE OF REVIEW: To review terminology, diagnostic algorithms, and clinical outcomes for patients with unexplained blood cytopenias. RECENT FINDINGS: Patients with cytopenias that remain unexplained after organized diagnostic testing can be described as having "idiopathic cytopenias of undetermined significance" (ICUS). Patients with unexplained cytopenias have a risk of progression to clonal myeloid neoplasms,...

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PMID: 31696381
DOI: 10.1007/s11899-019-00547-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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