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Article

Exploring the Genetic Heterogeneity of Alzheimer's Disease: Evidence for Genetic Subtypes.

Journal of Alzheimer's disease : JAD - 1 Jan 2024

Elman Jeremy A, Schork Nicholas J, Rangan Aaditya V

Abstract excerpt

Background: Alzheimer's disease (AD) exhibits considerable phenotypic heterogeneity, suggesting the potential existence of subtypes. AD is under substantial genetic influence, thus identifying systematic variation in genetic risk may provide insights into disease origins. Objective: We investigated genetic heterogeneity in AD risk through a multi-step analysis. Methods: We performed principal component analysis...

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Identifiers

PMID: 38995775
DOI: 10.3233/JAD-231252
PMCID: PMC11636402

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