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Article

Computing Individual Risks Based on Family History in Genetic Disease in the Presence of Competing Risks.

Computational and mathematical methods in medicine - 1 Jan 2017

Nuel Gregory, Lefebvre Alexandra, Bouaziz Olivier

Abstract excerpt

When considering a genetic disease with variable age at onset (e.g., familial amyloid neuropathy, cancers), computing the individual risk of the disease based on family history (FH) is of critical interest for both clinicians and patients. Such a risk is very challenging to compute because (1) the genotype X of the individual of interest is in general unknown, (2) the posterior distribution ℙ(X∣FH, T > t) changes...

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PMID: 29312466
DOI: 10.1155/2017/9193630
PMCID: PMC5700554

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