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Article

Apolipoprotein-ε4 is associated with higher fecundity in a natural fertility population.

Science advances - 9 Aug 2023

Trumble Benjamin C, Charifson Mia, Kraft Tom, Garcia Angela R, Cummings Daniel K, Hooper Paul, Lea Amanda J, Eid Rodriguez Daniel, Koebele Stephanie V, Buetow Kenneth, Beheim Bret, Minocher Riana, Gutierrez Maguin, Thomas Gregory S, Gatz Margaret, Stieglitz Jonathan, Finch Caleb E, Kaplan Hillard, Gurven Michael

Abstract excerpt

In many populations, the apolipoprotein-ε4 (APOE-ε4) allele increases the risk for several chronic diseases of aging, including dementia and cardiovascular disease; despite these harmful effects at later ages, the APOE-ε4 allele remains prevalent. We assess the impact of APOE-ε4 on fertility and its proximate determinants (age at first reproduction, interbirth interval) among the Tsimane, a natural fertility...

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Identifiers

PMID: 37556539
DOI: 10.1126/sciadv.ade9797
PMCID: PMC10411886

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