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Article

Circulating monocytes pre-disposed to form atherogenic foam cells are characterised by distinct transcriptional changes in people with HIV.

Atherosclerosis - 1 Mar 2026

Hearps Anna C, Boer Jennifer, Brunton-O'Sullivan Morgane, Angelovich Thomas A, Plebanski Magdalena, Trevillyan Janine, Hoy Jennifer F, Jaworowski Anthony

Abstract excerpt

BACKGROUND: People with HIV (PWH) have a 2-fold increased risk of cardiovascular disease despite antiretroviral therapy (ART) and adjustment for traditional risk factors. Monocytes play a key role in early atherosclerotic events and have a 'pro-atherogenic' phenotype in PWH, as evidenced by an enhanced formation of lipid-laden foam cells ex vivo. METHODS: To elucidate the contributing mechanisms, we analysed the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 41655318
DOI: 10.1016/j.atherosclerosis.2026.120658

Genes

ADAMTS2
CLDN4
FN1
LIPI
OR1L8
OR52N1
PAPPA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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