Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Defective neutrophil-derived exosomes facilitate macrophage activation through miR-122-5p in Behçet’s disease

2 Sept 2025

Abstract excerpt

Behçet’s disease (BD) is a life-threatening systemic vasculitis characterized by polymorphonuclear neutrophils (PMN) and macrophage activation. However, the interaction of PMN and macrophages remains elusive. To elucidate the potential dysregulation of BD PMN exosomes on macrophage activation, PMN exosomes from both BD patients and healthy controls are isolated, quantified and incubated with macrophages. We find...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Extracellular vesicles in disease
Share to Ocular Diseases and Behçet’s Syndrome
Share to Retinal and Optic Conditions

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40897707
DOI: 10.1038/s41467-025-63348-8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Defective neutrophil-derived exosomes facilitate macrophage activation through miR-122-5p in Behçet’s diseasePMID 40897707Read ↗

The role of miRNAs in Behçet’s diseaseSemantic proximity Read ↗

Approaches based on miRNAs in Behçet's Disease: Unveiling pathogenic mechanisms, diagnostic strategies, and therapeutic applicationsSemantic proximity Read ↗

Distinct transcriptional profile of blood mononuclear cells in Behçet’s disease: insights into the central role of neutrophil chemotaxisSemantic proximity Read ↗

Platelet transcription factors license the pro-inflammatory cytokine response of human monocytesSemantic proximity Read ↗

Exosomes in Autoimmune Diseases: A Review of Mechanisms and Diagnostic ApplicationsSemantic proximity Read ↗

Lupus Immune Complexes Drive Distinct Pro-Inflammatory Monocyte and Macrophage Populations Independent of Type I InterferonSemantic proximity Read ↗

Macrophage CD40 signaling: A pivotal regulator of disease protection and pathogenesisSemantic proximity Read ↗

Global microRNA profiling of peripheral blood mononuclear cells in patients with Behçet's disease.Semantic proximity Read ↗

The Roles of Monocytes and Macrophages in Behçet’s Disease With Focus on M1 and M2 PolarizationSemantic proximity Read ↗

HSCs-derived exosomes regulate the levels of inflammatory cytokines in HIBECs through miR-122-5p mediated p38 MAPK signaling pathwaySemantic proximity Read ↗

Macrophage polarization toward M1 phenotype through NF-κB signaling in patients with Behçet's disease.Semantic proximity Read ↗

Platelet-derived transcription factors license human monocyte inflammationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.