Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Sex contribution to average age at onset of Huntington's disease depends on the number of (CAG)n repeats.

Scientific reports - 8 Jul 2024

Stanisławska-Sachadyn Anna, Krzemiński Michał, Zielonka Daniel, Krygier Magdalena, Ziętkiewicz Ewa, Sławek Jarosław, Limon Janusz

Abstract excerpt

Huntington's disease (HD) is a hereditary neurodegenerative disorder caused by the extension of the CAG repeats in exon 1 of the HTT gene and is transmitted in a dominant manner. The present study aimed to assess whether patients' sex, in the context of mutated and normal allele length, contributes to age on onset (AO) of HD. The study population comprised a large cohort of 3723 HD patients from the European...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Age of Onset
Share to Alleles

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Europe

Share to Huntingtin Protein

Share to Huntington Disease

Share to Sex Factors

Share to Trinucleotide Repeat Expansion

Share to Trinucleotide Repeats

Source

Open in PubMed Open full text

Identifiers

PMID: 38977715
DOI: 10.1038/s41598-024-64105-5
PMCID: PMC11231309

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Sex contribution to average age at onset of Huntington's disease depends on the number of (CAG)n repeats.PMID 38977715Read ↗

The influence of gender on phenotype and disease progression in patients with Huntington's disease.Semantic proximity Read ↗

Interplay between Sex and Disease Burden in Huntington’s Disease: Clinical and Neuroimaging PerspectivesSemantic proximity Read ↗

Age of onset in Huntington disease: sex specific influence of apolipoprotein E genotype and normal CAG repeat length.Semantic proximity Read ↗

A new model for prediction of the age of onset and penetrance for Huntington's disease based on CAG lengthSemantic proximity Read ↗

Longer CAG repeat length is associated with shorter survival after disease onset in Huntington disease.Semantic proximity Read ↗

Influence of Age of Onset on Huntington's Disease Phenotype.Semantic proximity Read ↗

Clinical and genetic characteristics of late-onset Huntington's disease in a large European cohort.Semantic proximity Read ↗

Association of CAG Repeats With Long-term Progression in Huntington DiseaseSemantic proximity Read ↗

Epidemiology of Huntington disease.Semantic proximity Read ↗

CAG repeat expansion in Huntington disease determines age at onset in a fully dominant fashion.Semantic proximity Read ↗

Incidence of Huntington disease in a northeastern Spanish region: A 13-year retrospective study at tertiary care centreSemantic proximity Read ↗

The Clinical Features and Progression of Late-Onset Versus Younger-Onset in an Adult Cohort of Huntington's Disease Patients.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.