Pro-fibrotic effect of the susceptible gene PCSK5 in vascular fibrosis of Takayasu arteritis via TGF-β and SMAD3 signaling pathway activation.

doi:10.1016/j.jaut.2024.103277

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Pro-fibrotic effect of the susceptible gene PCSK5 in vascular fibrosis of Takayasu arteritis via TGF-β and SMAD3 signaling pathway activation.

Journal of autoimmunity - 1 Sept 2024

Wang Jinghua, Sun Ying, Chen Rongyi, Meng Dan, Wei Yuanyuan, Jiang Lindi, Kong Xiufang

Abstract excerpt

BACKGROUND: Vascular fibrosis directly causes vascular thickening in Takayasu arteritis (TAK), in which sustained transforming growth factor beta (TGF-β) activation is critical. Understanding TGF-β activation regulation and blocking it might yield a therapeutic effect in TAK. Proprotein convertase subtilisin/kexin type 5 (PCSK5) rs6560480 (T/C) is associated with TAK development. In this study, we assessed the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aorta

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fibroblasts

Share to Fibrosis

Share to Polymorphism, Single Nucleotide

Share to Signal Transduction

Share to Smad3 Protein

Share to Takayasu Arteritis

Share to Transforming Growth Factor beta

Source

Open in PubMed

Identifiers

PMID: 38972101
DOI: 10.1016/j.jaut.2024.103277

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pro-fibrotic effect of the susceptible gene PCSK5 in vascular fibrosis of Takayasu arteritis via TGF-β and SMAD3 signaling pathway activation.PMID 38972101Read ↗

Therapeutic potential of the Proprotein Convertase Subtilisin/Kexin family in vascular diseaseSemantic proximity Read ↗

Identification of susceptibility loci for Takayasu arteritis through a large multi-ancestral genome-wide association study.Semantic proximity Read ↗

The genetics of Takayasu arteritis.Semantic proximity Read ↗

Therapeutic value of curcumin on the initiation and development of inflammation in Takayasu’s arteritis mediated by HSP65-induced CCL2 overexpressionSemantic proximity Read ↗

Identification of Susceptibility Loci in IL6, RPS9/LILRB3, and an Intergenic Locus on Chromosome 21q22 in Takayasu Arteritis in a Genome-Wide Association Study.Semantic proximity Read ↗

Takayasu arteritis: advanced understanding is leading to new horizons.Semantic proximity Read ↗

Exosome miR-199a-5p modulated vascular remodeling and inflammatory infiltration of Takayasu's arteritisSemantic proximity Read ↗

PCSK6 Is a Key Protease in the Control of Smooth Muscle Cell Function in Vascular Remodeling.Semantic proximity Read ↗

Molecular reprogramming of adventitial pericytes by a selective MEK inhibitor halts the progression of thoracic aortic aneurysmSemantic proximity Read ↗

Recent advances in Takayasu arteritis.Semantic proximity Read ↗

Identification of multiple genetic susceptibility loci in Takayasu arteritis.Semantic proximity Read ↗

Two susceptibility loci to Takayasu arteritis reveal a synergistic role of the IL12B and HLA-B regions in a Japanese population.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.