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Article

Transforming growth factor-beta (TGF-β) in the pathogenesis of hereditary thoracic aneurysm disorders.

Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology - 1 Jan 2026

Espinoza Camejo Wendy A, Bramel Emily E, MacFarlane Elena Gallo

Abstract excerpt

The transforming growth factor-beta (TGF-β) signaling pathway regulates biological processes critical to embryonic development and tissue homeostasis, including cell proliferation, differentiation, adhesion and migration. Perturbations in TGF-β signaling are linked to a wide range of human diseases, including those affecting the cardiovascular system. This review summarizes decades-long evidence documenting the...

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Topics

Humans
Transforming Growth Factor beta
Signal Transduction
Aortic Aneurysm, Thoracic
Animals
Muscle, Smooth, Vascular

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Myocytes, Smooth Muscle

Extracellular Matrix

Genetic Predisposition to Disease

Phenotype

Source

Open in PubMed Open full text

Identifiers

PMID: 41241091
DOI: 10.1016/j.carpath.2025.107790
PMCID: PMC12723654

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 20 Oct 2026.

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