Article

Therapeutic value of curcumin on the initiation and development of inflammation in Takayasu’s arteritis mediated by HSP65-induced CCL2 overexpression

2020-05-15

Abstract excerpt

<h4>Background: </h4> Takayasu’s arteritis (TAK) is a chronic inflammatory disease characterized by macrophage infiltration. During the active stage, aorta adventitial fibroblasts (AAFs) proliferate excessively and produce numerous pro-inflammatory factors in the adventitia, the primary target of TAK therapy. Although the monocyte chemokine, CCL2, may contribute to macrophage infiltration in TAK arteries, whether...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f6dc31b9-8016-50c9-9bd8-6b15b1c48128
DOI: 10.21203/rs.3.rs-28048/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Therapeutic value of curcumin on the initiation and development of inflammation in Takayasu’s arteritis mediated by HSP65-induced CCL2 overexpressionDOI 10.21203/rs.3.rs-28048/v1Read

Multi-Omics Exploration of the Role of PTGS2 as a Hub Gene in Ferroptosis Within the Artery of Takayasu ArteritisSemantic proximity Read

Potential Role of Macrophage Phenotypes and CCL2 in the Pathogenesis of Takayasu Arteritis.Semantic proximity Read

Pro-fibrotic effect of the susceptible gene PCSK5 in vascular fibrosis of Takayasu arteritis via TGF-β and SMAD3 signaling pathway activation.Semantic proximity Read

Exosome miR-199a-5p modulated vascular remodeling and inflammatory infiltration of Takayasu's arteritisSemantic proximity Read

iPS-derived exosomes alleviate endothelial cell apoptosis and inflammation in Kawasaki disease through endogenous hsa-miR-1976 binding to CD40Semantic proximity Read

NF-Κb, A Potential Therapeutic Target, In Cardiovascular DiseasesSemantic proximity Read

Recent advances in Takayasu arteritis.Semantic proximity Read

Two susceptibility loci to Takayasu arteritis reveal a synergistic role of the IL12B and HLA-B regions in a Japanese population.Semantic proximity Read

Takayasu arteritis: advanced understanding is leading to new horizons.Semantic proximity Read

Molecular reprogramming of adventitial pericytes by a selective MEK inhibitor halts the progression of thoracic aortic aneurysmSemantic proximity Read

A macrophage-smooth muscle cell axis influences vascular remodeling through activation of the EGFR pathway in giant cell arteritisSemantic proximity Read

Systemic review and meta-analysis of the association between interleukin-10 and Takayasu arteritis.Semantic proximity Read