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Article

A Stearoyl-Coenzyme A Desaturase Inhibitor Prevents Multiple Parkinson Disease Phenotypes in α-Synuclein Mice.

Annals of neurology - 1 Jan 2021

Nuber Silke, Nam Alice Y, Rajsombath Molly M, Cirka Haley, Hronowski Xiaoping, Wang Junmin, Hodgetts Kevin, Kalinichenko Liubov S, Müller Christian P, Lambrecht Vera, Winkler Jürgen, Weihofen Andreas, Imberdis Thibaut, Dettmer Ulf, Fanning Saranna, Selkoe Dennis J

Abstract excerpt

OBJECTIVE: Parkinson disease (PD) has useful symptomatic treatments that do not slow the neurodegenerative process, and no significant disease-modifying treatments are approved. A key therapeutic target in PD is α-synuclein (αS), which is both genetically implicated and accumulates in Lewy bodies rich in vesicles and other lipid membranes. Reestablishing αS homeostasis is a central goal in PD. Based on previous...

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Identifiers

PMID: 32996158
DOI: 10.1002/ana.25920
PMCID: PMC7756464

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SCD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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