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Amino acid mutations PB1-V719M and PA-N444D combined with PB2-627K contribute to the pathogenicity of H7N9 in mice.

Veterinary research - 5 Jul 2024

Wang Xiaoquan, Tang Xin-En, Zheng Huafen, Gao Ruyi, Lu Xiaolong, Yang Wenhao, Zhou Le, Chen Yu, Gu Min, Hu Jiao, Liu Xiaowen, Hu Shunlin, Liu Kaituo, Liu Xiufan

Abstract excerpt

H7N9 subtype avian influenza viruses (AIVs) cause 1567 human infections and have high mortality, posing a significant threat to public health. Previously, we reported that two avian-derived H7N9 isolates (A/chicken/Eastern China/JTC4/2013 and A/chicken/Eastern China/JTC11/2013) exhibit different pathogenicities in mice. To understand the genetic basis for the differences in virulence, we constructed a series of...

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Identifiers

PMID: 38970119
DOI: 10.1186/s13567-024-01342-6
PMCID: PMC11227215

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