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PA-X I94V mutation modulates the pathogenicity of the highly pathogenic H7N9 influenza A virus in mice and chickens.

Veterinary microbiology - 1 Aug 2026

Chen Xia, Liu Haozhan, Jiang Liyi, Hong Xingping, Kong Ming, Wang Xiyue, Hu Zenglei, Gu Min, Wang Xiaoquan, Hu Shunlin, Liu Xiaowen, Yan Liping, Chen Gang, Peng Daxin, Liu Xiufan, Hu Jiao

Abstract excerpt

Currently, the continuous evolution of influenza A virus (IAV) still presents a major threat to human and animal health. Our sequence analysis reveals high variation at site 94 of the PA/PA-X gene in recent H5N1 and H7N9 IAV strains. To be noted, I94V mutation has become prevalent in recent human H7N9 viruses. However, the specific role of PA I94V mutation in regulating viral pathogenicity of H7N9 virus both in...

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PMID: 42090884
DOI: 10.1016/j.vetmic.2026.111044

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