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Virulence-Affecting Amino Acid Changes in the PA Protein of H7N9 Influenza A Viruses

27 Dec 2013

Abstract excerpt

UNLABELLED: Novel avian-origin influenza A(H7N9) viruses were first reported to infect humans in March 2013. To date, 143 human cases, including 45 deaths, have been recorded. By using sequence comparisons and phylogenetic and ancestral inference analyses, we identified several distinct amino acids in the A(H7N9) polymerase PA protein, some of which may be mammalian adapting. Mutant viruses possessing some of...

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PMID: 24371069
DOI: 10.1128/jvi.03155-13

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