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Virulence Determinants in the PB2 Gene of a Mouse-Adapted H9N2 Virus

23 Oct 2014

Abstract excerpt

The molecular bases of adaptation and pathogenicity of H9N2 influenza virus in mammals are largely unknown. Here, we show that a mouse-adapted PB2 gene with a phenylalanine-to-leucine mutation (F404L) mainly contributes to enhanced polymerase activity, replication, and pathogenicity of H9N2 in mice and also increases the virulence of the H5N1 and 2009 pandemic H1N1 influenza viruses. Therefore, we defined a novel...

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PMID: 25339773
DOI: 10.1128/jvi.01775-14

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