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Dual E627K and D701N mutations in the PB2 protein of A(H7N9) influenza virus increased its virulence in mammalian models.

Scientific reports - 22 Sept 2015

Zhu Wenfei, Li Long, Yan Zhigang, Gan Tanhuan, Li Lifeng, Chen Rirong, Chen Ruidong, Zheng Zuoyi, Hong Wenshan, Wang Jia, Smith David K, Guan Yi, Zhu Huachen, Shu Yuelong

Abstract excerpt

The ongoing avian H7N9 influenza outbreaks in China have caused significant human fatal cases and the virus is becoming established in poultry. Mutations with potential to increase mammalian adaptation have occurred in the polymerase basic protein 2 (PB2) and other viral genes. Here we found that dual 627K and 701N mutations could readily occur during transmission of the virus among ferrets via direct physical...

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Identifiers

PMID: 26391278
DOI: 10.1038/srep14170
PMCID: PMC4585756

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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