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Article

Mutations in the PA Protein of Avian H5N1 Influenza Viruses Affect Polymerase Activity and Mouse Virulence.

Journal of virology - 15 Feb 2018

Zhong Gongxun, Le Mai Quynh, Lopes Tiago J S, Halfmann Peter, Hatta Masato, Fan Shufang, Neumann Gabriele, Kawaoka Yoshihiro

Abstract excerpt

To study the influenza virus determinants of pathogenicity, we characterized two highly pathogenic avian H5N1 influenza viruses isolated in Vietnam in 2012 (A/duck/Vietnam/QT1480/2012 [QT1480]) and 2013 (A/duck/Vietnam/QT1728/2013 [QT1728]) and found that the activity of their polymerase complexes differed significantly, even though both viruses were highly pathogenic in mice. Further studies revealed that the...

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Identifiers

PMID: 29212927
DOI: 10.1128/JVI.01557-17
PMCID: PMC5790930

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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