Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

TFEB safeguards trophoblast syncytialization in humans and mice

5 Jul 2024

Abstract excerpt

Nutrient sensing and adaptation in the placenta are essential for pregnancy viability and proper fetal growth. Our recent study demonstrated that the placenta adapts to nutrient insufficiency through mechanistic target of rapamycin (mTOR) inhibition–mediated trophoblast differentiation toward syncytiotrophoblasts (STBs), a highly specialized multinucleated trophoblast subtype mediating extensive maternal–fetal...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Birth, Development, and Health
Share to Erythrocyte Function and Pathophysiology
Share to Pregnancy and preeclampsia studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 38968109
DOI: 10.1073/pnas.2404062121

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

TFEB safeguards trophoblast syncytialization in humans and micePMID 38968109Read ↗

TFEB controls syncytiotrophoblast differentiationSemantic proximity Read ↗

Molecular regulation and functional benefits of trophoblast syncytialization in optimizing maternal-fetal nutrient allocationSemantic proximity Read ↗

Placental trophoblast syncytialization potentiates macropinocytosis via mTOR signaling to adapt to reduced amino acid supplySemantic proximity Read ↗

The GATA transcriptional program dictates cell fate equilibrium to establish the maternal–fetal exchange interface and fetal developmentSemantic proximity Read ↗

GATA-regulated transcriptional program dictate cell fate equilibrium to establish the maternal-fetal exchange interface and fetal developmentSemantic proximity Read ↗

Harnessing Autophagic Network Is Essential for Trophoblast Stem Cell DifferentiationSemantic proximity Read ↗

Human placentation: foundations and implications for reproductive endocrinology and infertilitySemantic proximity Read ↗

A three-dimensional culture system recapitulates placental syncytiotrophoblast development and microbial resistanceSemantic proximity Read ↗

Development and function of trophoblast giant cells in the rodent placentaSemantic proximity Read ↗

Omics Approaches to Study Formation and Function of Human Placental SyncytiotrophoblastSemantic proximity Read ↗

Placenta-Specific Genes, Their Regulation During Villous Trophoblast Differentiation and Dysregulation in Preterm PreeclampsiaSemantic proximity Read ↗

Atypical protein kinase C iota (PKCλ/ι) ensures mammalian development by establishing the maternal–fetal exchange interfaceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.