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Human placentation: foundations and implications for reproductive endocrinology and infertility

1 Aug 2025

Abstract excerpt

that facilitates nutrient and gas exchange, waste removal, hormone production and immune modulation. We describe how placentation is orchestrated to keep pace with fetal growth, but is vulnerable to disruption by medical interventions for infertility. Initially, trophoblast stem cells differentiate into proliferating mononuclear cytotrophoblasts (CTBs) that fuse to form the multinucleated syncytiotrophoblast...

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PMID: 40748841
DOI: 10.1080/19396368.2025.2533992

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