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Molecular regulation and functional benefits of trophoblast syncytialization in optimizing maternal-fetal nutrient allocation

6 Jun 2025

Abstract excerpt

The placenta governs maternal-fetal nutrient allocation during pregnancy, primarily mediated by placental villi composed of multinucleated syncytiotrophoblasts (STBs) and mononucleated cytotrophoblasts (CTBs) in humans. STBs are formed through cell fusion of CTBs, a process termed syncytialization. The placental villi are bathed in maternal blood sinus, functioning as a critical unit for bidirectional exchange of...

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PMID: 40500628
DOI: 10.1016/j.placenta.2025.06.003

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