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Article

Dual genetic level modification engineering accelerate genome evolution of Corynebacterium glutamicum.

Nucleic acids research - 12 Aug 2024

Wang Qing, Zhang Jie, Zhao Zhe, Li Yichen, You Jiajia, Wang Yi, Li Xiangfei, Xu Meijuan, Rao Zhiming

Abstract excerpt

High spontaneous mutation rate is crucial for obtaining ideal phenotype and exploring the relationship between genes and phenotype. How to break the genetic stability of organisms and increase the mutation frequency has become a research hotspot. Here, we present a practical and controllable evolutionary tool (oMut-Cgts) based on dual genetic level modification engineering for Corynebacterium glutamicum. Firstly,...

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Identifiers

PMID: 38967005
DOI: 10.1093/nar/gkae577
PMCID: PMC11317142

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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