Article
Accelerated Growth of Corynebacterium glutamicum by Up-Regulating Stress- Responsive Genes Based on Transcriptome Analysis of a Fast-Doubling Evolved Strain.
Journal of microbiology and biotechnology - 28 Sept 2020
Park Jihoon, Lee SuRin, Lee Min Ju, Park Kyunghoon, Lee Seungki, Kim Jihyun F, Kim Pil
Abstract excerpt
Corynebacterium glutamicum, an important industrial strain, has a relatively slower reproduction rate. To acquire a growth-boosted C. glutamicum, a descendant strain was isolated from a continuous culture after 600 generations. The isolated descendant C. glutamicum, JH41 strain, was able to double 58% faster (td=1.15 h) than the parental type strain (PT, td=1.82 h). To understand the factors boosting...
Topics
- Adenosine Triphosphate
- Bacterial Proteins
- Carboxylic Acids
- Corynebacterium glutamicum
- Directed Molecular Evolution
- Gene Expression Profiling
- Gene Expression Regulation, Bacterial
- Mutation
- Oxidative Stress
- Protein Biosynthesis