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Article

Mutational landscape and clinical outcome of pediatric acute myeloid leukemia with 11q23/KMT2A rearrangements.

Cancer medicine - 1 Jan 2023

Yuen Ka-Yuk, Liu Yong, Zhou Yong-Zhuo, Wang Yin, Zhou Dun-Hua, Fang Jian-Pei, Xu Lu-Hong

Abstract excerpt

BACKGROUND: Alterations of 11q23/KMT2A are the most prevalent cytogenetic abnormalities in acute myeloid leukemia (AML) and the prognostic significance of 11q23/KMT2A-rearranged AML based on various translocation partners varies among different studies. However, few studies evaluated the molecular characteristics of 11q23/KMT2A-rearranged pediatric AML. We aim to analyze the mutational landscape of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35833755
DOI: 10.1002/cam4.5026
PMCID: PMC9883550

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