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Molecular basis of host recognition of human coronavirus 229E

27 Feb 2025

Abstract excerpt

Human coronavirus 229E (HCoV-229E) is the earliest CoV found to infect humans. It binds to the human aminopeptidase N (hAPN) through the receptor binding domain (RBD) of its spike (S) protein to achieve host recognition. We present the cryo-electron microscopy structure of two HCoV-229E S protein in complex with a dimeric hAPN to provide structural insights on how the HCoV-229E S protein opens up its RBD to...

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PMID: 40016196
DOI: 10.1038/s41467-025-57359-8

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