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Article

Intact and mutated Shigella diguanylate cyclases increase c-di-GMP.

The Journal of biological chemistry - 1 Aug 2024

Ojha Ruchi, Krug Stefanie, Jones Prentiss, Koestler Benjamin J

Abstract excerpt

The intracellular human pathogen Shigella invades the colonic epithelium to cause disease. Prior to invasion, this bacterium navigates through different environments within the human body, including the stomach and the small intestine. To adapt to changing environments, Shigella uses the bacterial second messenger cyclic di-GMP (c di-GMP) signaling system, synthesized by diguanylate cyclases (DGCs) encoding GGDEF...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 38960033
DOI: 10.1016/j.jbc.2024.107525
PMCID: PMC11327459

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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