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Article

Shigella flexneri Diguanylate Cyclases Regulate Virulence.

Journal of bacteriology - 5 Nov 2021

Ojha Ruchi, Dittmar Ashley A, Severin Geoffrey B, Koestler Benjamin J

Abstract excerpt

Shigella flexneri is an intracellular human pathogen that invades colonic cells and causes bloody diarrhea. S. flexneri evolved from commensal Escherichia coli, and genome comparisons reveal that S. flexneri has lost approximately 20% of its genes through the process of pathoadaptation, including a disproportionate number of genes associated with the turnover of the nucleotide-based second messenger cyclic di-GMP...

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Source

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Identifiers

PMID: 34543105
DOI: 10.1128/JB.00242-21
PMCID: PMC8570270

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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