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Article

Phenotypic enhancement of thymidylate synthetase pathway inhibitors following ablation of Neil1 DNA glycosylase/lyase.

Cell cycle (Georgetown, Tex.) - 15 Dec 2010

Taricani Lorena, Shanahan Frances, Pierce Rob H, Guzi Timothy J, Parry David

Abstract excerpt

Inhibition of thymidine biosynthesis is a clinically-validated therapeutic approach for multiple cancers. Inhibition of thymidylate synthetase (TS) leads to a decrease in cellular TTP levels, replication stress and increased genomic incorporation of uridine (dUMP). Thus, inhibitors of this pathwa...

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PMID: 21131780
DOI: 10.4161/cc.9.24.14155

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ATM
ATR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21131780-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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