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Article

DUSP1 and SOX2 expression determine squamous cell carcinoma of the salivary gland progression

1 Jul 2024

Abstract excerpt

Abstract Salivary gland squamous cell carcinomas (SG-SCCs) constitute a rare type of head and neck cancer which is linked to poor prognosis. Due to their low frequency, the molecular mechanisms responsible for their aggressiveness are poorly understood. In this work we studied the role of the phosphatase DUSP1, a negative regulator of MAPK activity, in controlling SG-SCC progression. We generated DUSP1 KO clones...

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PMID: 38951654
DOI: 10.1038/s41598-024-65945-x

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