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Article

Regulation of Head and Neck Squamous Cancer Stem Cells by PI3K and SOX2

15 Sept 2016

Abstract excerpt

Background: We have an incomplete understanding of the differences between cancer stem cells (CSCs) in human papillomavirus-positive (HPV-positive) and -negative (HPV-negative) head and neck squamous cell cancer (HNSCC). The PI3K pathway has the most frequent activating genetic events in HNSCC (especially HPV-positive driven), but the differential signaling between CSCs and non-CSCs is also unknown. Methods: We...

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PMID: 27634934
DOI: 10.1093/jnci/djw189

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