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Article

A stem cell gene expression profile of human squamous cell carcinomas

27 Jul 2008

Abstract excerpt

To investigate the relationship between stem cells in normal epithelium and in squamous cell carcinomas (SCCs), we examined expression of a panel of human epidermal stem cell markers in SCCs and SCC cell lines. Markers that are co-expressed in normal stem cells were not co-expressed in SCC. Downregulation of two markers, Lrig1 and MAP4, and upregulation of a third, MCSP, correlated with poor differentiation...

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PMID: 18657901
DOI: 10.1016/j.canlet.2008.06.014

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