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Article

IL2 Variant Circumvents ICOS+ Regulatory T-cell Expansion and Promotes NK Cell Activation.

Cancer immunology research - 1 Nov 2016

Sim Geok Choo, Liu Chengwen, Wang Ena, Liu Hui, Creasy Caitlin, Dai Zhimin, Overwijk Willem W, Roszik Jason, Marincola Francesco, Hwu Patrick, Grimm Elizabeth, Radvanyi Laszlo

Abstract excerpt

Clinical responses to high-dose IL2 therapy are limited due to selective expansion of CD4+CD25+Foxp3+ T-regulatory cells (Treg), especially ICOS+ Tregs, rather than natural killer (NK) cells and effector T cells. These ICOS+ Tregs are highly suppressive and constitutively express high levels of IL2Rα (CD25) and CD39. Here, we characterized the effect of a mutant form of IL2 (F42K), which preferentially binds to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Inducible T-Cell Co-Stimulator Protein

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Source

Identifiers

PMID: 27697858
DOI: 10.1158/2326-6066.CIR-15-0195

Genes

ICOS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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