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Article

Temporal linkage between the phenotypic and genomic responses to caloric restriction.

Proceedings of the National Academy of Sciences of the United States of America - 13 Apr 2004

Dhahbi Joseph M, Kim Hyon-Jeen, Mote Patricia L, Beaver Robert J, Spindler Stephen R

Abstract excerpt

Caloric restriction (CR), the consumption of fewer calories while avoiding malnutrition, decelerates the rate of aging and the development of age-related diseases. CR has been viewed as less effective in older animals and as acting incrementally to slow or prevent age-related changes in gene expr...

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PMID: 15044709
DOI: 10.1073/pnas.0305300101
PMCID: PMC397416

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15044709-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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