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Article

Identification of drug targets for Sjögren's syndrome: multi-omics Mendelian randomization and colocalization analyses.

Frontiers in immunology - 1 Jan 2024

Bai Yingjie, Wang Jiayi, Feng Xuefeng, Xie Le, Qin Shengao, Ma Guowu, Zhang Fan

Abstract excerpt

Background: Targeted therapy for Sjögren's syndrome (SS) has become an important focus for clinicians. Multi-omics-wide Mendelian randomization (MR) analyses have provided new ideas for identifying potential drug targets. Methods: We conducted summary-data-based Mendelian randomization (SMR) analysis to evaluate therapeutic targets associated with SS by integrating DNA methylation, gene expression and protein...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38933282
DOI: 10.3389/fimmu.2024.1419363
PMCID: PMC11199405

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