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Article

Genetic Evidence for Causal Effects of Lipid-lowering Drug Targets on Primary Sjögren's Syndrome Risk: A Mendelian Randomization Study.

Current pharmaceutical biotechnology - 1 Jan 2026

Li Yuying, Liao Weiquan, Guo Ying'ao, Xiao Lijuan, Qiu Zaixing, Xie Jingjing, Zhang Jianyong

Abstract excerpt

INTRODUCTION: Primary Sjögren's Syndrome (pSS) is a chronic autoimmune condition affecting lacrimal and salivary glands. While previous studies suggest potential associations between dyslipidemia and autoimmune diseases, the causal relationship between lipid-lowering medications and pSS remains unclear. METHODS: This study employed drug-targeted Mendelian randomization (MR) analysis to assess the impact of...

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Share to Cholesterol Ester Transfer Proteins
Share to HMGCR gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Hydroxymethylglutaryl CoA Reductases

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Share to Mendelian Randomization Analysis

Share to Polymorphism, Single Nucleotide

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Source

Identifiers

PMID: 40765098
DOI: 10.2174/0113892010387265250730110805

Genes

CETP
HMGCR
APOB
LDLR
NPC1L1
PCSK9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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