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Article

Genetic insight into dissecting the immunophenotypes and inflammatory profiles in the pathogenesis of Sjogren syndrome.

Journal of translational medicine - 13 Jan 2025

Xu Jingyi, Si Shucheng, Han Yijun, Zeng Lin, Zhao Jinxia

Abstract excerpt

BACKGROUND: Sjogren syndrome (SS) is a chronic systemic autoimmune disease and its pathogenesis often involves the participation of numerous immune cells and inflammatory factors. Despite increased researches and studies recently focusing on this area, it remains to be fully elucidated. We decide to incorporate genetic insight into investigation of the causal link between various immune cells, inflammatory...

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Topics

Humans
Sjogren's Syndrome
Inflammation
Immunophenotyping
Genome-Wide Association Study
Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Female

Mendelian Randomization Analysis

B-Lymphocytes

Bayes Theorem

Tumor Necrosis Factor Receptor Superfamily, Member 7

Source

Open in PubMed Open full text

Identifiers

PMID: 39806364
DOI: 10.1186/s12967-024-05993-z
PMCID: PMC11726950

Genes

CD24
CD27
CD4

Provenance

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