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Dual-dimensional profiling of host genomic variations and HPV integration in PD-L1-stratified cervical cancer via Oxford Nanopore Technology.

Journal of translational medicine - 7 Jan 2026

Lu Ruijiao, Zhang Jie, Ma Xiumin, Feng Yangchun

Abstract excerpt

BACKGROUND: The integration of human papillomavirus (HPV) DNA into the host genome is a key step in the development of HPV-associated cervical cancer (CC). However, the genomic characteristics of host genomic variations and HPV integration within the context of programmed death-ligand 1 (PD-L1) expression stratification have not been systematically investigated. METHODS: Whole-genome sequencing was performed...

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B7-H1 Antigen
DNA Copy Number Variations
Genetic Variation
Human Papillomavirus Viruses
Nanopore Sequencing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Uterine Cervical Neoplasms

Virus Integration

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PMID: 41501895
DOI: 10.1186/s12967-025-07674-x
PMCID: PMC12870535

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KLF5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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