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Article

Multi-omics characterization of silent and productive HPV integration in cervical cancer

1 Jan 2023

Abstract excerpt

Cervical cancer (CC) that is caused by high-risk human papillomavirus (HPV) remains a significant public health problem worldwide. HPV integration sites can be silent or actively transcribed, leading to the production of viral-host fusion transcripts. Herein, we demonstrate that only productive HPV integration sites were nonrandomly distributed across both viral and host genomes, suggesting that productive...

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Identifiers

PMID: 36777180
DOI: 10.1016/j.xgen.2022.100211

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