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Article

Acetylation of KLF5 maintains EMT and tumorigenicity to cause chemoresistant bone metastasis in prostate cancer.

Nature communications - 17 Mar 2021

Zhang Baotong, Li Yixiang, Wu Qiao, Xie Lin, Barwick Benjamin, Fu Changying, Li Xin, Wu Daqing, Xia Siyuan, Chen Jing, Qian Wei Ping, Yang Lily, Osunkoya Adeboye O, Boise Lawrence, Vertino Paula M, Zhao Yichao, Li Menglin, Chen Hsiao-Rong, Kowalski Jeanne, Kucuk Omer, Zhou Wei, Dong Jin-Tang

Abstract excerpt

Advanced prostate cancer (PCa) often develops bone metastasis, for which therapies are very limited and the underlying mechanisms are poorly understood. We report that bone-borne TGF-β induces the acetylation of transcription factor KLF5 in PCa bone metastases, and acetylated KLF5 (Ac-KLF5) causes osteoclastogenesis and bone metastatic lesions by activating CXCR4, which leads to IL-11 secretion, and stimulating...

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Source

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Identifiers

PMID: 33731701
DOI: 10.1038/s41467-021-21976-w
PMCID: PMC7969754

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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