Article
A prostate cancer susceptibility allele at 6q22 increases RFX6 expression by modulating HOXB13 chromatin binding.
Nature genetics - 1 Feb 2014
Huang Qilai, Whitington Thomas, Gao Ping, Lindberg Johan F, Yang Yuehong, Sun Jielin, Väisänen Marja-Riitta, Szulkin Robert, Annala Matti, Yan Jian, Egevad Lars A, Zhang Kai, Lin Ruizhu, Jolma Arttu, Nykter Matti, Manninen Aki, Wiklund Fredrik, Vaarala Markku H, Visakorpi Tapio, Xu Jianfeng, Taipale Jussi, Wei Gong-Hong
Abstract excerpt
Genome-wide association studies have identified thousands of SNPs associated with predisposition to various diseases, including prostate cancer. However, the mechanistic roles of these SNPs remain poorly defined, particularly for noncoding polymorphisms. Here we find that the prostate cancer risk-associated SNP rs339331 at 6q22 lies within a functional HOXB13-binding site. The risk-associated T allele at rs339331...
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