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Article

Targeting FOXA1-mediated repression of TGF-β signaling suppresses castration-resistant prostate cancer progression

4 Dec 2018

Abstract excerpt

Prostate cancer (PC) progressed to castration resistance (CRPC) is a fatal disease. CRPC tumors develop resistance to new-generation antiandrogen enzalutamide through lineage plasticity, characterized by epithelial-mesenchymal transition (EMT) and a basal-like phenotype. FOXA1 is a transcription factor essential for epithelial lineage differentiation. Here, we demonstrate that FOXA1 loss leads to remarkable...

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PMID: 30511964
DOI: 10.1172/jci122367

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