Article
Biology and Clinical Implications of the 19q13 Aggressive Prostate Cancer Susceptibility Locus.
Cell - 26 Jul 2018
Gao Ping, Xia Ji-Han, Sipeky Csilla, Dong Xiao-Ming, Zhang Qin, Yang Yuehong, Zhang Peng, Cruz Sara Pereira, Zhang Kai, Zhu Jing, Lee Hang-Mao, Suleman Sufyan, Giannareas Nikolaos, Liu Song, Tammela Teuvo L J, Auvinen Anssi, Wang Xiaoyue, Huang Qilai, Wang Liguo, Manninen Aki, Vaarala Markku H, Wang Liang, Schleutker Johanna, Wei Gong-Hong
Abstract excerpt
Genome-wide association studies (GWAS) have identified rs11672691 at 19q13 associated with aggressive prostate cancer (PCa). Here, we independently confirmed the finding in a cohort of 2,738 PCa patients and discovered the biological mechanism underlying this association. We found an association of the aggressive PCa-associated allele G of rs11672691 with elevated transcript levels of two biologically plausible...
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