Article
Mutations in isocitrate dehydrogenase 1 and 2 occur frequently in intrahepatic cholangiocarcinomas and share hypermethylation targets with glioblastomas.
Oncogene - 20 Jun 2013
Wang P, Dong Q, Zhang C, Kuan P-F, Liu Y, Jeck W R, Andersen J B, Jiang W, Savich G L, Tan T-X, Auman J T, Hoskins J M, Misher A D, Moser C D, Yourstone S M, Kim J W, Cibulskis K, Getz G, Hunt H V, Thorgeirsson S S, Roberts L R, Ye D, Guan K-L, Xiong Y, Qin L-X, Chiang D Y
Abstract excerpt
Mutations in the genes encoding isocitrate dehydrogenase, IDH1 and IDH2, have been reported in gliomas, myeloid leukemias, chondrosarcomas and thyroid cancer. We discovered IDH1 and IDH2 mutations in 34 of 326 (10%) intrahepatic cholangiocarcinomas. Tumor with mutations in IDH1 or IDH2 had lower 5-hydroxymethylcytosine and higher 5-methylcytosine levels, as well as increased dimethylation of histone H3 lysine 79...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.