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Article

Prognostic value of germline mutations in metastatic hormone-sensitive prostate cancer (mHSPC).

Urologic oncology - 1 Oct 2024

Custodio-Cabello Sara, Pacheco-Barcia Vilma, Palka-Kotlowska Magda, Fernández-Hernández Laura, Del Álamo Julio Fernández, Oliveros-Acebes Eduardo, Cabezón-Gutiérrez Luis

Abstract excerpt

BACKGROUND: About 8% to 12% of patients presenting with mHSPC exhibit germline pathogenic variants (PV) in cancer predisposition genes. The aim of this study is to assess the presence of germline PV as a prognostic factor in the setting of mHSPC and to determine whether mutational status can predict rapid progression to castration resistance. METHODS: Genetic analysis using a multigene next-generation sequencing...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 38926076
DOI: 10.1016/j.urolonc.2024.05.010

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