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Article

Pathogenic Germline Variants in a Racially Diverse Real-World Cohort of Patients With Prostate Cancer.

Journal of the National Comprehensive Cancer Network : JNCCN - 2 Jun 2026

Crawford Taylor B, Tayeb Maliha, Barrett Emanuel, Al-Saleem Tara, Kondam Pranavi, Hausler Ryan, Symecko Heather, Orr Caitlin, Wolfe Catherine Spielman, Mann Derek, Spielman Kelsey, Wong Gloria, Haas Naomi B, Narayan Vivek, Robinson Kyle, Takvorian Samuel, Wong Yu-Ning, Sokolova Alexandra O, Montgomery Robert B, Menendez Carolyn, Kelley Michael J, Aiello Lisa B, Garraway Isla P, Domchek Susan M, Maxwell Kara N

Abstract excerpt

BACKGROUND: Pathogenic germline variant (PGV) rates in cancer risk genes and their association with clinicopathologic features inform genetic testing practices for patients with prostate cancer (PCa). In this study, we determined the rate of PGVs in PCa risk genes in a real-world, diverse cohort of patients with PCa and identified clinical predictors of carrier status. PATIENTS AND METHODS: Genetic testing...

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Identifiers

PMID: 42229501
DOI: 10.6004/jnccn.2026.7006

Genes

BRCA2
ATM
CHEK2
BRCA1
MLH1
MSH2
MSH6
PMS2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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