Article
Liver-specific DICER1 syndrome model mice develop cystic liver tumors with defective primary cilia.
The Journal of pathology - 1 Sept 2024
Oikawa Keiki, Ohno Shin-Ichiro, Ono Kana, Hirao Kaito, Murakami Ayano, Harada Yuichirou, Kumagai Katsuyoshi, Sudo Katsuko, Takanashi Masakatsu, Ishikawa Akio, Mineo Shouichirou, Fujita Koji, Umezu Tomohiro, Watanabe Noriko, Murakami Yoshiki, Ogawa Shinichiro, Schultz Kris Ann, Kuroda Masahiko
Abstract excerpt
DICER1 syndrome is a tumor predisposition syndrome caused by familial genetic mutations in DICER1. Pathogenic variants of DICER1 have been discovered in many rare cancers, including cystic liver tumors. However, the molecular mechanisms underlying liver lesions induced by these variants remain unclear. In the present study, we sought to gain a better understanding of the pathogenesis of these variants by...
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