Article
Molecular pathogenesis of oral squamous cell carcinoma: implications for therapy.
Journal of dental research - 1 Jan 2008
Choi S, Myers J N
Abstract excerpt
The development of oral squamous cell carcinoma (OSCC) is a multistep process requiring the accumulation of multiple genetic alterations, influenced by a patient's genetic predisposition as well as by environmental influences, including tobacco, alcohol, chronic inflammation, and viral infection. Tumorigenic genetic alterations consist of two major types: tumor suppressor genes, which promote tumor development...
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