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Article

Molecular pathogenesis of oral squamous cell carcinoma: implications for therapy.

Journal of dental research - 1 Jan 2008

Choi S, Myers J N

Abstract excerpt

The development of oral squamous cell carcinoma (OSCC) is a multistep process requiring the accumulation of multiple genetic alterations, influenced by a patient's genetic predisposition as well as by environmental influences, including tobacco, alcohol, chronic inflammation, and viral infection. Tumorigenic genetic alterations consist of two major types: tumor suppressor genes, which promote tumor development...

Topics

Carcinoma, Squamous Cell
Environment
Gene Expression Regulation
Genes, Tumor Suppressor
Genetic Predisposition to Disease
Genetic Therapy
Humans
Molecular Biology
Mouth Neoplasms
Oncogenes

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PMID: 18096889
DOI: 10.1177/154405910808700104

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