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Prenatal Development and Function of Human Mononuclear Phagocytes

8 Apr 2021

Abstract excerpt

The human mononuclear phagocyte (MP) system, which includes dendritic cells, monocytes, and macrophages, is a critical regulator of innate and adaptive immune responses. During embryonic development, MPs derive sequentially in yolk sac progenitors, fetal liver, and bone marrow haematopoietic stem cells. MPs maintain tissue homeostasis and confer protective immunity in post-natal life. Recent evidence – primarily...

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PMID: 33898444
DOI: 10.3389/fcell.2021.649937

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